No abstract

Background: Siglec-9 binds sialylglycoconjugates on target cells probably causing signals in both sides of cells. Results: Co-culture with Siglec-9-expressing U937 caused degradation of focal adhesion kinase and related proteins in an astrocytoma cell line. Conclusion: Interaction between Siglec-9 and its counterreceptor triggered activation signals in cancer cells via calpain. Significance: Cancer cells may utilize sialylglycoconjugates recognized by Siglec-9 to escape from immunosurveillance.