Objectives To compare the clinical results obtained by using the techniques of open limited fasciectomy (FP) and percutaneous needle fasciectomy (FPC) in patients with Dupuytren's contracture after one year follow up. Methods Thirty-three patients and a total of 50 fingers with Dupuytren's contracture were divided non-randomly and evaluated after undergoing procedures with FP or FPC. The results were evaluated based on the Tubiana classification, DASH score (Disabilities of the Arm, Shoulder, and Hand), time until return to professional activities, total passive extension deficit (DTEP), the relationship between the extension deficit and DASH, recurrence and complications. Results Twenty-six fingers were treated with FPC technique and 24 fingers with FP. The DTEP was significantly lower in FP group (10.23°) when compared to FPC group (23.46°) at 12 months postoperatively ( p = 0.038). The remaining items assessed did not show any statistically significant differences. Conclusion Total passive extension deficit at 12 months is lower in the group of open limited fasciectomy. There are no significant differences between groups FP and FPC over the classification of Tubiana, the DASH score, time until return to professional activities and the incidence of recurrence.

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myoma. Individual fibroids and blood of all patients were collected during the surgery. DNA extraction and amplification were carried out, the PCR reaction was conducted, and the sequence fragments were identified. Measurements/Results: 77 patients were included in the study (51 and 26 in the first and the second groups, respectively). 167 nodules were collected in patients of the first group. 74.5 % of women in the first group (38/51) were found to have mutations in an exon 2 of the gene MED 12. This mutation was found in 91 out of 167 nodules (54.5 %) of this group. 50% of women in the second group (13/26) were found to have the same somatic mutations in MED 12, demonstrating statistical significance among the groups of patients with studied mutations (p = .042). It was interesting to discover insertion at length 6 n. p. localized in the exon 2 gene MED 12, which has not been published in previous studies. Conclusions: We revealed that women with multiple leiomyoma exhibit mutations in an exon 2 of the gene MED 12 with greater frequency than women with single fibroid. We may propose that somatic mutations in exon 2 of the gene MED 12 can stimulate the affiliate multipotent cells and trigger the migration of their affiliate cells with the subsequent development of multiple leiomyomas.