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Superficial CD34 positive fibroblastic tumor (SCPFT) is a recently recognized, unique neoplasm with distinctive histomorphological features such as high pleomorphism, low mitotic rate, and diffuse CD34 reactivity. Hereby we present three cases of our experience with clinicopathological, morphological, and immunohistochemical characteristics. The patients were a 31-year-old female, 53-year-old female, and 33-year-old male. The tumors were all superficially located; left forearm, medial aspect of the left ankle, and left thigh, respectively. Histomorphologically they had expansile and focal infiltrative growth pattern consisting of highly pleomorphic spindle cells with intranuclear inclusions, yet low mitotic rate. Tumoral cells showed strong and diffuse reactivity for CD34. One of our cases showed focal and weak reactivity for pancytokeratin. Unlike the other two tumors, one case was positive for desmin. During the clinical follow-up, one case showed local recurrence four times. SCPFT is a newly recognized, borderline mesenchymal neoplasm of soft tissues that can show local recurrence or even rarely metastasize. To the best of our knowledge, this three case series is the first to be reported from Turkey. Our aim to report these three cases was to make contribution to the literature about this rare entity and increase awareness.

A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The aim of this study is to compare the necroinflammatory activity score / histological activity index (HAI) and fibrosis score detected in liver biopsies with serum transaminase levels of chronic hepatitis B, C and steatohepatitis. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : This retrospective study included total of 398 cases whose liver biopsies were performed because increased liver enzyme levels and had the diagnoses of chronic hepatitis B, hepatitis C or steatohepatitis ofter liver biopsy between [2003][2004][2005][2006][2007]. The HAI and fibrosis scores of all cases were evaluated according to ISHAK classification criteria and then the results were compared with the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels at the time of biopsy. R Re es su ul lt ts s: : When all cases were considered, serum AST values emerged as the most statistically significant variable for hepatic fibrosis (r:0.311; p<0.01). Additionally, there was a correlation between AST values and HAI (r:0.295; p<0.01). On the other hand, serum ALT values did not correlate with (r:0.094; p>0.05) the extent of hepatic fibrosis but correlated weakly with HAI (r:0.242; p<0.01). C Co on nc cl lu us si io on n: : Serum AST level is found to be a significant indicator of histological activity index and fibrosis as well as hepatic damage. These findings suggested that, among other factors, serum AST values should be considered in decisions regarding the need for liver biopsy and treatment in patients with chronic hepatitis.K Ke ey y W Wo or rd ds s: : Aspartate aminotransferases; hepatitis, chronic; fibrosis Ö ÖZ ZE ET T A Am ma aç ç: : Bu çalışmanın amacı kronik hepatit B, hepatit C ve steatohepatitteki serum transaminaz düzeyleri ile karaciğer biyopsisinde tespit edilen nekroinflamatuvar aktivite derecesi / histolojik aktivite indeksi (HAİ) ve fibrozis skorunu karşılaştırmaktır. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu retrospektif çalışmaya 2003-2007 yılları arasında kronik hepatit B, hepatit C veya yüksek karaciğer enzim seviyeleri nedeniyle karaciğer biyopsisi yapılıp steatohepatit tanısı alan toplam 398 olgu dahil edildi. Tüm olguların HAİ ve fibrozis skorları ISHAK sınıflama kriterlerine göre değerlendirildi ve ardından sonuçlar biyopsi anındaki serum alanin aminotransferaz (ALT) ve aspartat aminotransferaz (AST) düzeyleri ile karşılaştırıldı. B Bu ul lg gu ul la ar r: : Tüm olgular göz önüne alındığında, serum AST değerleri hepatik fibrozis için en anlamlı değişken olarak ortaya çıktı (r: 0.311; p <0.01). Ayrıca, AST değerleri ve HAI arasında da bir ilişki vardı (r: 0.295; p <0.01). Diğer taraftan, serum ALT değerleri ile hepatik fibrozisin derecesi arasında korelasyon olmamakla birlikte (r: 0.094; p> 0.05) HAI ile zayıf korelasyon saptandı (r: 0.242; p <0.01). S So on nu uç ç: : Serum AST düzeyinin histolojik aktivite indeksi, fibrozis ve aynı zamanda karaciğer hasarının önemli bir göstergesi olduğu saptamıştır. Bu bul...

While some new light has been shed on the clinicopathological features of solid pseudopapillary tumor concerning its etiology, origin and treatment methods, there is much to be understood. Further studies focusing on genetics, pathogenesis and prognosis are needed for a better understanding of this entity.

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