Few derivatives of 3-arylmethyl-4-hydroxycoumarin and 4-aryl-3,4-dihydrocoumarin as potential free radical scavengers were synthesized. The antiradical activity of these compounds was measured according to 1,1-diphenyl-2-picrylhidrazyl and galvinoxyl tests. It strongly depends on phenol-type substituent attached to the coumarin skeleton, nevertheless the chromen-2-one scaffold by itself plays an important role for the antiradical activity.
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