A semi-novel, accurate, sensitive, simple, requiring no prior separation and economical procedures have been developed for the simultaneous analysis of binary mixture of Lansoprazole (Lanso) and Simvastatin (Semva). The first method is the Derivative of ratio spectra, in which the absorption spectrum of one drug as interfering drug were subtracted from the absorption spectrum of the mixture and then the net spectrum derivative, the first derivative (for Lanso) and second derivative (for Semva). Beer’s law was obeyed in the concentration ranges of (1-90) and (4-70) μg.ml-1 and the results showed that the method was precise and accurate with RSD% of (0.0161-0.0235), (0.0360-0.0525) and R.E% (0.3125-0.4545), (-0.0909-0.0312) for Lanso and Semva respectively. The second method based on ratio difference, where the absorption spectrum of mixtures the drugs was divided by the on the absorption spectrum of a suitable the interfering drug. The difference in peak amplitudes between the two selected wavelengths in the ratio spectra were recorded for each drug. Beer’s law was obeyed in the concentration ranges of (0.1-30) and (1-40) μg.ml-1 and the results of the method were precise and accurate with RSD% of (0.2880-0.4580), (0.1294-0.9880) and R.E% of (-0.0090-0.0909), (-0.0651-0.0710) for Lanso and Semva respectively of this method.
The proposed methods were successfully applied for the determination of the two compounds.
Two new simultaneous spectrophotometric methods for determination of Olanzapine and Ephedrine depend on third (D3) and fourth (D4) derivative of zero spectrum of two drugs were developed. The peak – to- base line, peak to peak and area under peak were found proportional with concentration of the drugs up to (4-24 µg/ml-1) at known experimental wavelengths. The results showed that the method was precise and accurate through RSD% (0.5026-4.0273),( 0.2399 6.9888) and R.E %(-2.3889-0.8333) ,) -2.9444-0.2273) while the LOD (0.0057- 0.8510 μg.ml-1), ( 0.0953-0.9844 μg.ml-1) and LOQ (0.0173- 2.5788μg.ml-1),( 0.5774-2.9829 μg.ml-1) were found for the two drugs respectively. The methods were applied ide to the determination of Olanzapine and Ephedrine in pharmaceutical preparations successfully.
A simple , specific, accurate and precise RP-HPLC method was developed for determination of Irbesartan (IRB) in pharmaceutical dosage forms in tablets products and sachet using symmetry (L 1 ) column at 30°C . The signal was detected at 225 nm. A mobile phase dissolve 0.5 g of buffer potassium phosphate in 100 ml distilled water and adjust pH 2.7 , methanol and acetonitrile at ratio (40 :30 :30 ) . and flow rate 1.2ml/min -1 at pH=7.2 a mobile phase The percent recovery was detected 101 % and the linearity of concentration was 10-50 µg.ml -1 and supported this method by using (FT.I.R.) spectrum method for organic spectrophotometer to prove the chemical structure of this drug and some physical properties . we are obtained the result is identical of other literature . The proposed method was applied successfully for determination of the IRB in tablets products.
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