Objective: To compare elastin expression in the anterior vaginal wall of women with and with no pelvic prolapse. Methods: The research was conducted in RS Dr. Wahidin Sudirohusodo and other network hospitals of Obstetrics and Gynecology Department of Hasanuddin University, Makassar. Full-thickness specimens were obtained from the anterior vaginal wall of women having a large prolapse repaired (stage III or IV; prolapse group, 34) and the same location in patients with no prolapse having abdominal and vaginal hysterectomy (control group, 35). The expression of elastin was measured by immunohistochemistry on tissue sectioned. The examiner was unaware of sample identity and the patients’ clinical history. The result then analyzed with p 4000 gr weight (p=0.572); age, parity, menopausal status, and body mass index were significantly different between the groups (0.001; 0.035; 0.011; 0.002; respectively). Immunohistochemical staining indicated that elastin expression in the prolapse group was lower (p=0.009). Elastin expression appeared to be stable with increasing of age, parity, menopausal status, history of bearing baby 4000 gr. weight and Body mass Index in the prolapse group. But multiple logistic regression revealed that elastin have the highest influence to prolapse among the risk factors mentioned (Exp.B =6.252). Conclusion: In this case-control study, the elastin expression were significantly lower in the vaginal wall of patients with a large prolapse. Instead of influence by other risk factors, elastin is the strongest risk factor for developing prolapse among other risk factors. This result is expected to be able to give explanation for the development of prolapse in women without risk factors such is young women and nullipara. [Indones J Obstet Gynecol 2013; 1-4: 204-8] Keywords: elastin, prolapse, women

Objective: To compare the effectiveness of rectal misoprostol administration to the amount of blood loss in 4th stage of labor at high risk pregnancy. Method: We recruited all pregnant women with high risk criteria including anemia, age  35 years old, or the number of pregnancies  4. Women would deliver appropriate to standard procedure of normal delivery. After that, we gave 400-mcg tablet of misoprostol rectally in treatment group. To count the amount of blood loss during 4th stage of labor, we put the underpad. Result: The amount of blood loss in 4th stage of labor in the treatment group was 201.1 (SD 80.3) ml less than the control group (285.9 (SD 93.2) ml). The result showed that the administration of 400-mcg misoprostol tablet rectally immediately after the birth of the placenta at high risk pregnancy impacted significantly to reduce the amount of blood loss in 4th stage of labor (p

Objective: To investigate the comparison of the Anti-Mullerian Hormone (AMH) as the ovarian reserve marker before and after cystectomy. Methods: This study used prospective cohort design which included all women with the ovarian cyst who underwent cystectomy laparotomy. The subjects were examined AMH level before and after the procedure. Data were analyzed using one- way Anova, T- paired test, and T-independent test with p value