Air Q 2.2.3 was used to predicted hospital admissions respiratory disease cases due to SO2 and NO2 exposure in two sectors of Egypt during December 2015 to November 2016. Levels were 19, 22 μg/m3 at Ain Sokhna sector and 92, 78 μg/m3 at Shoubra El-Khaima sector for SO2 and NO2, respectively. These levels were less than the Egyptian Permissible limits (125 µg/m³ in urban and 150 µg/m³ in industrial for SO2, 150 µg/m³ in urban and industrial for NO2). Results showed that relative risks were 1.0330 (1.0246 - 1.0414) and 1.0229 (1.0171 - 1.0287) at Ain Sokhna sector while they were 1.0261 (1.0195 -1.0327) and 1.0226 (1.0169 - 1.0283) at Shoubra El-Khaima sector for SO2 and NO2, respectively.The highest cases of HARD were found in Shoubra El-Khaima sector; 311 cases at 120 - 129 μg/m3 of SO2 and 234 cases at 120 - 129 μg/m3 of NO2. While, in Ain Sokhna, HARD were 18 cases at 50 - 59 μg/m3 of SO2 and 15 cases at 60 - 69 μg/m3 of NO2. The excess cases found in Shoubra El-Khaima sector as compared to those in Ain Sokhna sector, may be attributed to the higher density of population and industries in Shoubra El-Khaima sector.Keywords: AirQ2.2.3 model; Hospital admissions respiratory disease (HARD); Nitrogen dioxide (NO2); Sulfur dioxide (SO2); Coastal Sectors.

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This study aims to estimate the association between some heavy metals in suspended particulate matter (SPM) and kidney damage among workers at different departments in a secondary aluminum production plant. It also investigates the association between Xeroderma Pigmentosum complementation group D (XPD) gene polymorphisms and worker’s susceptibility to kidney dysfunction. It was conducted on 30 workers from the administrative departments and 147 workers from different departments in the production line. Estimation of some heavy metals (Al, Co, Ni, Cu, Pb, and Cd) in suspended particulate matter (SPM) is done. Also, urinary levels of those metals were measured for all workers. Kidney injury molecule 1 (KIM-1), clusterin levels, and XPD protein level were estimated. Genotyping of XPD gene polymorphisms was performed. The measured annual average concentrations of the estimated heavy metals were lower than the permissible limits. Gravity area had the maximum concentration of metals with a higher Al average daily dose and hazardous index > 1. Kidney injury biomarkers (clusterin and KIM-1) were increased significantly (p < 0.05) while XPD protein showed the lowest levels among workers at the gravity and cold rolling areas. XPD Asn/Asp genotype was more dominant among those workers (85.7%). Conclusion: aluminum workers are at risk of kidney disorders due to heavy metal exposure. The individual’s susceptibility to the diseases is related to the DNA repair efficiency mechanisms. The defect in XPD protein represents a good indicator of susceptibility to the disease. KIM-1 and clusterin estimation is a predictor biomarker for early-staged kidney diseases.

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