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: Alzheimer’s disease (AD) is a multifarious and developing neurodegenerative disorder. The treatment of AD is still a challenge and availability of drug therapy on the basis of symptoms is not up to the mark. In the context of the existence, which is getting worse for the human brain, is necessary to taken care of the all critical measures. The disease causes due to multidirectional pathology of the body, which demands the multi-target-directed ligand (MTDL) approach and provides a hope for the new drugs for AD, which is summarized herein with the pyrimidine based natural product inspired molecule as a lead. The review is sufficient to provide a list of chemical ingredients of the plant to cure the AD and screened them against the various potential targets of the AD. The synthesis of a highly functionalized scaffold in one step in one pot without isolating the intermediate is a challenging task, but in a few examples, we have highlighted the importance of this kind of reaction, generally known as multi-component reaction. The multi-component is widely accepted technique by the drug discovery people due to its high atom economy and it reduces multi-step process to a one-step process, so, the compounds library can be made in minimum time and cost. This review has highlighted the importance of multicomponent reactions by giving the example of active scaffolds of pyrimidine/fused pyrimidines. This would bring to the importance of the fast as well as a smart synthesis of the bio-relevant molecules.

Nanotechnology is a major area of research entitling the production of an utmost different class of materials. There are various types of nanostructures, such as nanoparticles, nanocrystals, nano spores, nanorods, nanowires, nanoribbons, nanotubes, nano scaffolds, dendrimers, quantum dots, nanospheres, and nanocapsules. These are size-dependent; thus, altering their size and shape to the nanoscale can alter their properties. Also, they can be manufactured via various different methods. On a wider scale, in combination, nanostructured materials and nanotechnology can have profound impacts, including biomedical applications with advanced research in the delivery of biomolecules, the delivery of drugs, the diagnosis of cancer, tissue engineering, the detection of biomarkers and imaging. These materials have numerous applications in fabricating biotechnology, an advanced area of research.

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