Chronic rhinosinusitis in various countries in the world and Indonesia shows an increase from time to time. At General Hospital of Haji Surabaya, the prevalence of chronic rhinosinusitis has increased from 10.13% in 2016 to 10.26% in 2017. Various factors are thought to cause chronic rhinosinusitis. Chronic rhinosinusitis can interfere with the quality of life and lead to serious complications if left untreated. To determine the profile of chronic rhinosinusitis in General Hospital of Haji Surabaya for January-December 2017 Period. Analytic observational with cross-sectional study approach. Used the total sampling method. Based on patients diagnosed with chronic rhinosinusitis with complete medical record data. The sample in this study were 132 patients. Most chronic rhinosinusitis patients were aged 36-45 years as many as 26 patients (19.69%) and the least number of patients was more than 65 years old as many as 6 patients, women (67.40%) and 43 patients in men (32, 60%). Symptoms of nasal congestion in 79 patients (59.84%), cough as many as 25 patients (18.93%), septal deviation as many as 51 patients (38.63%) and at least 4 patients (3.03%) of nasal polyps. Most rhinosinusitis patients in this study were aged 36-45 years, women with symptoms of nasal congestion and septal deviation as the most comorbidities.

In industry, "benzene" is frequently employed as a basic or compound substance. Exposure to "benzene" has hematotoxic effects on blood cell values, such as pancytopenia. In cases of cytopenia that cannot be explained, a blood smear evaluation is usually employed as a confirmation test and extra diagnostic help. The purpose of this study was to see how benzene inhalation affected blood smear examination in white male rats (Rattus novergicus) of the Wistar strain. True experimental design with simply a post-test control group. A total of 20 rats were separated into four groups. The non-benzene inhalation exposure group (K-) served as the negative control. The treatment groups ("P1, P2, P3") were given benzene inhalation at concentrations of 1, 10, and 100 parts per million, respectively. The exposure lasted 28 days, 8 hours per day, 5 days per week. The results were achieved by counting rat blood cells and examining their morphology under a microscope, after which an average number was calculated. Research and Discussion According to the ANOVA and Kruskal-Wallis test, the number of neutrophils and monocytes increased dramatically, whereas lymphocytes declined. Each group had a varied number of eosinophils, although the difference was not statistically significant. In the group exposed to 100 ppm benzene, the "Bonferoni and Mann-Whitney" post hoc test revealed a significant rise in the number of neutrophil segments and a decrease in the number of lymphocytes "(p0.05)". In the group exposed to 10 ppm benzene, there was a substantial rise in monocytes (p 0,05). The morphology of erythrocytes, leukocytes, and platelets yielded no aberrant results. Benzene inhalation exposure significantly affects the number of neutrophils segments, lymphocytes and monocytes, but has no effect on the number of other types of leukocytes. No abnormal morphology was found in erythrocyte, leukocyte, and platelets

An impropriate use of antibiotics leads to bacterial resistance problems and side effects. To minimize resistance and adverse side effects, the faloak plant (Sterculia quadrifida R.Br.) has the potential to be used as antibacterial agents. This study aimed to determine the antibacterial effectiveness of faloak bark extract (Sterculia qudrifida R.Br.) against the growth of Salmonella typhi bacteria. This study used a static group comparison research method (Static Group Comparison), namely by measurement (observation) carried out after the treatment group received a program or intervention. According to the results of the research and discussion in this study, the following conclusions can be drawn. Extract of the bark of the faloak plant (Sterculia quadrifida R.Br.) with a concentration of 22.5%; 45%; 75%; and 100% has antibacterial effectiveness against the growth of Salmonella typhi bacteria. The stem bark extract of the faloak plant (Sterculia quadrifida R.Br.) is said to be most effective at inhibiting the growth of Salmonella typhi at a concentration of 100%.

One of the most common occupational diseases is noise-induced hearing loss. Noise-induced hearing loss is a decrease in the function of the sense of hearing caused by exposure to noise. Noise exposure greater than 85 dB and exposure for more than 8 hours will increase the risk of hearing loss. Hearing loss due to noise can cause an increase in the risk of work-related accidents which will have an impact on the safety of workers or the community. The purpose of this publication is to determine the relationship between duration of exposure and noise intensity to noise-induced hearing loss. The library method used is in the form of 31 literature sources consisting of 8 textbooks and 23 national and international journals with a time span of 2013-2020. From the results of the analysis there is a relationship between the length of exposure and the intensity of noise on the hearing loss of factory workers. It can be concluded that the duration of exposure and the intensity of noise affect hearing loss due to noise. Other factors that can affect the occurrence of hearing loss due to noise such as age, habits outside of work, and the use of PPE can also affect the occurrence of hearing loss due to noise.