Purpose - This research analyzed: (1) The influence of Perceived organizational suport on work engagement at PT Padang Intermedia Pers (2) The influence of work engagement on organizational citizenship behavior at PT Padang Intermedia Pers (3) The influence of perceived organizational support on organizational citizenship behavior at PT Padang Intermedia Pers (4) The influence of perceived organizational support on organizational citizenship behavior through work engagement at PT Padang Intermedia Pers.Methodology- This research is causal research. The populations were all employee in the PT Padang Intermedia Pers, amounting to 102 people. The number of samples was determined using cluster propotional sampling technique. This research analyzed using path analysis with SmartPLS3.Finding- Regarding the partial mediation model proposed, the data confirm the relationship set out in the hypothesis. This research found that (1) Perceived organizational support has positive and significant effect work engagement in PT Padang Intermedia Pers (2) Work engagement has a positive and significant effect on organizational citizenship behavior in PT Padang Intermedia Pers (3) Perceived organizational support has a positive and significant effect on organizational citizenship behavior in PT Padang Intermedia Pers (4) Work engagement mediates the relationship between perceived organizational support and organizational citizenship behavior. Keywords: Organizational citizenship behavior, Perceived Organizational Support, Work Engagement

Penelitian ini dilakukan dengan tujuan untuk menguji secara empiris pengaruh Pengaruh Debt To Equity Ratio (DER), CurrentRatio (CR), Return on Equity (ROE), dan Net Profit Margin (NPM) Terhadap PriceEarning Ratio (PER) Perusahaan Sub Sektor Perkebunan yang Terdaftar pada Bursa Efek Indonesia Periode Tahun 2014-2017. Berdasarkan kriteria yang ada, maka didapatkan 15 perusahaan sub sektor perkebunan. Pengujian hipotesis dilakukan dengan analisis regresi linier berganda, tetapi sebelum pengujian hipotesis terlebih dahulu dilakukan pengujian asumsi klasik.             Hasil pengujian hipotesis dilakukan secara parsial yaitu uji t menunjukkan bahwaDER berpengaruh positif dan tidak signifikan terhadap PER.CR berpengaruh positif dan tidak signifikan terhadap PER.ROE berpengaruh positif dan signifikan terhadap PER. NPM berpengaruh positif dan signifikan terhadap PER. Kata Kunci: Debt To Equity Ratio (DER), CurrentRatio (CR), Return on Equity (ROE), dan Net Profit Margin (NPM), dan Price Earning Ratio (PER).

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Introduction: One of the leading causes of infant blindness is cataract. The prevalence of congenital cataract has been estimated in the range between 1 and 15 per 10.000 children globally. Congenital cataract in twin babies is a rare case. This case will report the outcome of comprehensive management of congenital cataract in dizygotic twin babies. Case presentation: Eight months old dizygotic twin babies came to our clinic with the primary complaint of whitish appearance in the pupil of both eyes since birth. They were born aterm with cesarean delivery. The birth weight was 2.700 g and 3.100 g respectively. They were the fourth and fifth children in the family. There was no family history of congenital cataract. The visual acuity of both eyes was positive response to light stimuli. The cataract was bilateral and dense on both babies. Fundus reflex and TORCH examinations were negative. Ultrasonography (USG) of the retina was normal on both babies. Conclusions: Isolated congenital cataract in twin babies is an unusual condition that should be treated comprehensively. Congenital cataract may cause deprivation amblyopia, refractive amblyopia, and permanent vision impairment. Early diagnosis and quick treatment, such as surgical timing and visual rehabilitation, are critical to perform successful management. Comprehensive care is required to monitor the visual result of cataract surgery.

BACKGROUND: Posterior capsule opacification (PCO) often occurs after cataract surgery. Metformin has been known to have an ability to inhibit fibrosis. This study aimed to investigate the effects of metformin on cell contractility, collagen deposition and degradation in human lens epithelial cells (HLEC) of cataract patients.METHODS: HLEC were isolated from the anterior lens capsule of patients undergoing cataract surgery. The HLEC culture was carried out using explant culture technique. The in vitro PCO model was created by scratching technique on HLEC cultures. The treatment groups were given 0.1, 0.5 and 1 mM metformin, respectively, while the control group were given 10% fetal bovine serum (FBS). On the 7th day after scratching technique, the collagen deposition, collagen degradation and cell contractility were evaluated.RESULTS: Collagen deposition in HLEC was significantly reduced after given 0.1 mM, 0.5 mM and 1 mM metformin (17.92±6.16 mg/mL, 12.92±4.31 mg/mL, 11.25±5.30 mg/mL, respectively), compared to the control group (31.46±7.52 μg/mL, p=0.002). Collagen degradation significantly was increased in the 0.1 mM, 0.5 mM and 1 mM metformin groups (4.77±9.27 mg/mL, 6.59±1.16 mg/mL, 6.35±1.90 mg/mL, respectively) compared to the control group (2.21±2.78 μg/mL, p=0.002). While, collagen contractility in HLEC was significantly reduced in 0.1mM, 0.5mM and 1 mM metformin groups (16.39±3.89%, 13.89±2.59%, 11.93±2.44%, respectively), compared to the control group (44.25±4.95%, p=0.000).CONCLUSION: Metformin reduced collagen deposition and contractility, but increased collagen degradation in HLEC of cataract patients through mechanism of extracellular matrix remodeling.KEYWORDS: metformin, human lens epithelial cell, fibrosis