Durian (Durio zibethinus Murr.) telah lama digunakan sebagai salah satu pengobatan tradisional untuk mengobati berbagai macam penyakit, termasuk untuk penderita diabetes mellitus. Penelitian ini bertujuan untuk menentukan aktivitas ekstrak etanol durian dalam menurunkan kadar glukosa darah pada mencit yang diinduksi aloksan dosis 125 mg / kgBB dan diberi beban glukosa 20%. Sebanyak 36 ekor mencit dibagi menjadi 6 kelompok perlakuan. Kelompok I sebagai kontrol sehat, kelompok II diinduksi dengan aloksan dan diberikan NaCMC 1% (kontrol negatif), kelompok III diinduksi dengan aloksan dan diberikan Acarbose® (kontrol positif), kelompok IV diinduksi dengan aloksan dan diberikan ekstrak etanol akar durian (EDR), ekstrak klika (ESB) dan ekstrak daun (EDL) dosis 125 mg / kgBB, kelompok V diinduksi dengan aloksan dan diberikan ekstrak etanol akar durian (EDR), ekstrak klika (ESB) dan ekstrak daun (EDL) dosis 250 mg / kgBB, kelompok VI diinduksi dengan aloksan dan diberikan ekstrak etanol akar durian (EDR), ekstrak klika (ESB) dan ekstrak daun (EDL) dosis 500 mg / kgBB. Pengukuran kadar glukosa darah dilakukan sebelum induksi alloxan (t-0), 3x24 jam setelah induksi (t-3), dan setiap 30 menit setelah pemberian perlakuan ekstrak dan larutan glukosa hingga menit ke-180 (t30, t60, t90, t120, t150 dan t180), yang dilakukan pengukuran menggunakan alat glukometer (Nesco®). Persen penurunan kadar glukosa darah yang paling tinggi ditunjukkan setelah menit ke-180 pada kelompok EDR dengan dosis 125 mg / kgBB, ESB dosis  250 mg / kgBB dan EDL dosis 500 mg / kgBB yaitu  sebesar 50,60%, 105,62%, dan 62,97%.

A new compound belonging to a dihydrotetrazolopyrimidine derivative, that is, ethyl 5-methyl-7-(4-morpholinophenyl)-4,7-dihydrotetrazolo[1,5-a]pyrimidine-6-carboxylate, was successfully synthesized using a Biginelli reaction between 4-morpholinobenzaldehyde, ethyl acetoacetate, and 5-aminotetrazole with p-toluenesulfonic acid (pTSA) as a catalyst in ethanol under reflux. The molecular structure of the title compound was characterized on the basis of spectroscopic evidence, using FTIR, HRESI-MS, 1H- and 13C-NMR, and 2D NMR.

During the Covid-19 pandemic, which has not yet ended, the business of selling honey is a type of business that is able to survive and even increase its market. The trend of selling honey in the era of the Covid-19 pandemic is quite stable and has the potential to be a good source of income because honey can be used as medicine and can increase the body's immunity. Fitorajo Bee Farm is a UMKM engaged in bee cultivation which is located in Pinang City, South Labuhanbatu Regency, North Sumatra Province with original honey bee products packaged in plastic bottle containers. The marketing system carried out by Fitorajo Bee Farm is carried out through word of mouth, Facebook social media, or through the WhatsApp application. Seeing the promising potential of the honey business in the Covid-19 pandemic era, and in order to reach a wider market, Fitorajo Bee Farm should improve and innovate by adopting e-commerce technology. Conventional marketing, which so far only reaches consumers on a limited scale, must be changed with a marketing system that can reach consumers from any corner. The purpose of this research is to build a marketing media for Fitorajo Bee Farm honey bees by implementing web-based e-commerce. The system development method used is the waterfall model, while the programming language used is PHP framework codeigniter with MySQL DBMS. The results showed that the codeigniter framework and MySQL DBMS can be applied to build e-commerce web-based honey bee marketing media.

ABSTRAKSalah satu cara reproduksi tumbuhan Asystasia gangetica (L.) T. Anderson adalah menggunakan reproduksi vegetatif melalui stek. Tujuan penelitian ini adalah untuk mengevaluasi pengaruh perbedaan umur terhadap pertumbuhan dan produksi stek A. gangetica. Penelitian dilakukan dengan rancangan acak lengkap 3 perlakuan umur panen (50, 70 dan 90 hari) dengan 24 kali ulangan. Parameter yang diamati adalah tinggi tanaman, jumlah ranting, berat batang, jumlah stek dan diameter stek pada saat panen. Data dianalisis dengan ANOVA dan uji lanjut LSD menggunakan software Ri386 versi 3.3.2. Hasil penelitian menunjukkan bahwa pertumbuhan tinggi tanaman A. gangetica cenderung membentuk pola sigmoid berupa polynomial berderajat tiga. Berdasarkan penelitian ini, tanaman berumur 90 hari memiliki tinggi (128,1±12,3) dan berat batang terbaik (156,7±18,6) serta menghasilkan jumlah stek yang terbanyak (17,1±4,25) dan diameter stek terbesar (4,3±0,7). Produksi stek A. gangetica berasal dari ranting primer dan sekunder.Kata kunci: Asystasia gangetica, pertumbuhan, produksi stek, umur panen

This study was aimed to prepare polyeugenol with high molecular weight and to evaluate its antibacterial and antioxidant activities. First, polyeugenol was synthesized from eugenol in the presence of H2SO4-CH3COOH (4:1) as catalyst. The synthesized polyeugenol was weighed by using viscometer, revealing its high molecular weight of (7.76–21.9) × 105 g/mol. Furthermore, the antibacterial activity of the polyeugenol was conducted against Staphylococcus aureus and Escherichia coli bacteria. It was conducted by applying well diffusion method at 1, 2, 3, 4 and 5% concentrations to observe inhibition zones, in which the tests showed that the antibacterial activity of the polyeugenol against S. aureus were 17.42, 17.76, 18.79, 21.42 and 22.55 mm, while those against E. coli were 15.87, 17.23, 17.56, 18.24 and 19.21 mm, respectively. In short, these results indicated a strong antibacterial activity. Then, tests on antioxidant activity against free radical DPPH (2,2-diphenyl-1-pycrylhydrazyl) gave the IC50 value of 80.47 µg/mL, indicating a strong antioxidant activity. Therefore, the polymer synthesized in this work has a high potential to be applied in various biomedical applications.