Carbon distribution in macro molecules becomes important to address the diseases in living systems. CARd3D program locate these carbon contents in 3D structures of proteins. Here the sickle cell anemia causing mutation in hemoglobin is analysed for betterment of disease cause and compared. Results reveal the involvement of carbon content in disease mutation which is causing sickle cell anemia and identified possible location of protein for salvation.

One of the interesting focus points of research in protein science is the active site analysis and probe fixing. Overall one can go on searching this interesting phenomenon of probe fixing but without proper explanation on how and why this happens at some site neglecting other places. One of the probe fixing methods could be come along the way of newly discovered carbon role in protein stability that is taken here as starting point for due course of action. Carbon role in protein domain formation and active portion are interestingly yielded good result. Analysis includes ICOD of protein in native and domain state of active portion in complex protein. ICOD analysis reveals that carbon does play an interesting role in probe of action. Alternative method to detect active portion and probe development can be better exploited from this carbon domain of protein for life science to excel.

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