THON, I. L. and B. UVNAS. Degranulation and histamine release, two consecutive steps in the response of rat mast cells to compound 48/80. Acta physiol. scand. 1967. 71. 303-315.

No abstract

No abstract

During the course of experiments on biologically occurring histamine releasers we investigated the action of extracts from hip seeds. These seeds are covered with hairs and produce itching on contact with the skin. We surmised that the itching might be due not only to the mechanical irritation but also to the presence of some histamine liberating substance --as reported by BROAD-BENT (1953) for Cowhage. However, extracts from the hip seeds did not produce any histamine release. On the contrary, they blocked the action of subsequently administered compound 48/80. This observation prompted us to examine further the inhibitory mechanism and the factor responsible for it. Although these investigations are still in progress, the observation of the inhibitory action of hip seed extracts seems to be worth a brief communication. Techn iqne.The inhibitory action on histamine liberation was studied in the perfused paw of the cat. The paw was prepared and perfused with Tyrode's solution as reported by HOGBERG, THUFVESSON and VVN& (1956).