Chronic induced urticaria (CIndU) is a group of diseases characterized by the occurrence of itchy wheals and/or angioedema in response to specific triggers, such as mechanical irritation, exposure of high and low temperatures, vibration, as well as ultraviolet radiation of various spectrum, appearing for 6 or more weeks. This group of diseases is characterized by a long duration, a significant impact to the patients quality of life, as well as the risk of severe life-threatening reactions. Diagnosis of induced urticaria - patient-safe reproduction of symptoms by exposure to a trigger (temperature, mechanical, etc.). Currently, there are no registered medical devices in the Russian Federation for the threshold diagnosis of most physical forms of urticaria, which makes it difficult to diagnose and dynamically monitor the state of these groups of patients and the response to treatment. The question of therapy with CIndU also remains open, due to the insufficient effectiveness of the recommended and available methods of therapy. This article provides an rewiew of current literature data.

ABSTRACT

The cold stress is one of the main functional tests in the study of the microvascular bed of the skin. An important task is to automate visualization of the capillary network and measurement of microcirculation parameters directly in the local area of inflammation. In this paper, we describe a system developed for non-invasive visualization of the microcirculation and the processing of such images in order to determine the morphological parameters of the capillary network and their changes under external conditions. Proposed approach provides high-quality visualization of the skin microvessels and allows obtaining reliable information about the capillary map. The results of experimental studies are presented. Obtained data may be used for the development of the new methods for detecting hidden hemodynamic disorders and diagnostics of various diseases.

Chronic urticaria (CU) is an urgent medical and social problem. The instruments of everyday clinical practice are international and domestic guidelines which briefly reflect modern ideas about various aspects of CU. Recently, a new opportunity has emerged to expand theoretical and practical experience in the management of patients with CU, to carry out educational activities to disseminate modern knowledge about urticaria, to conduct research in the field of studying the pathogenesis, treatment, and prevention of exacerbations of the disease. This opportunity is realized through the centers of excellence for working with such patients (GALEN UCARE centers). One of the five Russian centers, have prepared and conducted an online training program "Chronic urticaria: scientific and medical achievements and practical aspects of patient management." at the Federal State Budgetary Institution State Research Center "Institute of Immunology" FMBA of Russia. The event was held by the employees of the Federal State Budgetary Institution State Research Center "Institute of Immunology" of the FMBA of Russia on November , 2020.

Background: Chronic inducible urticaria (CIndU) is the group of diseases characterized by the development of wheals, angioedema or both in response to specific triggers. According to global scientific international literature the occurrence of CIndU is 0,5% in general population and about 20-30% in all chronic urticarias. Aim: There are no statistical data of the prevalence of CIndU in Russian Federation. The aim of this research is evaluation of the epidemiology of chronic inducted urticarias. Materials and Methods: This analysis based on counts of unique cases of access to medical care in adults due to this pathology in digital EMIAS platform (inpatient and outpatient) in Moscow between 2017 and 2021, including key words search. Results: indicated that the prevalence of CIndU in Moscow is correlating with published global epidemiological data, its rates are high and tends to increase as in global practice. Limitations of this research are the lack of ubiquitous implementation of standard protocols of provocation testing in outpatient, the low percent of using validated questionnaires and systematic management of patients with CIndU. Conclusions: Further studies dedicated to this topic are a great unmet need in order to answer a wide spectrum of questions including the diagnosis process and evaluation of the the severity of CIndU, comorbid conditions and optomisation of the treatment process.