The most significant aspect of a drug's physicochemical nature is its solubility. If the medicine is in a dissolved form, it can dissolve and enter the membrane, resulting in a therapeutic effect. The pharmacokinetic phase of the drug in the body, which includes absorption, distribution, metabolism, and excretion, will be correlated with solubility. Some medications, however, have a low solubility. To obtain a therapeutic impact, an effort must be made to increase the drug's solubility. Based on the literature research, the goal of this paper is to explain approaches that can be utilized to improve solubility. In general, physical, chemical, and micelle formation efforts can all be used it to enhance solubility. Particle size reduction, crystal shape modification, and the utilization of matrices in the disperse phase are examples of physical alterations. pH adjustment, buffering, salt formation, complexation, and derivatization all are examples of chemical alterations. The employment of supercritical processes in solutions and also excipients such as surfactants, cosolvents, stabilizing solutions, and others are examples of how micelle formation can be modified.

Control of microorganisms is vital to prevent infection. Prevention can be done in various ways, one of which is the use of disinfectants and antiseptics. The widespread use of disinfectants and antiseptics due to the outbreak of COVID-19 has led to the use of antiseptics that are not appropriate for society. The use of biocide agents that are not used correctly can endanger the health of its users. It is recommended that pharmacists, related health workers, and the public should learn more comprehensively about the use of disinfectants and antiseptics when a pandemic occurs. This review is done by searching Google Scholar as a database. This article discusses biocide agents, especially disinfectants and antiseptics, including definitions, ingredients and concentrations, antimicrobial effectiveness, factors affecting disinfection, hazards, techniques, and accuracy of the dosage of their use, the use and advantages and disadvantages of several classes of disinfectants and antiseptics that must be understood to be useful in their use, in this review also describe some formulations of disinfectant and antiseptic products circulating in the community that can be obtained and used from the commercial market.