Carica papaya (papaya) leaf extract has been used for a long time in a traditional medicine to treat fever in some infectious diseases such as dengue, malaria, and chikungunya. The development of science and technology has subsequently made it possible to provide evidence that this plant is not only beneficial as an informal medication, but also that it has scientifically proven pharmacological and toxicological activities, which have led to its formal usage in professional health care systems. The development of formulations for use in nutraceuticals and cosmeceuticals has caused this product to be more valuable nowadays. The use of good manufacturing practice (GMP) standards, along with the ease of registering this product facilitated by policies of the national government, will absolutely increase the value of papaya leaf extract as a vital nutraceutical and cosmeceutical products in the near future. In this article, we review the potential of papaya leaf extract to be a high-value commodity in terms of its health effects as well as its industrial benefits.

Peningkatan kesehatan masyarakat untuk pengendalian sindrom metabolik yang bersumber daya dari masyarakat sendiri perlu dilakukan dengan cara pemberdayaan masyarakat melalui edukasi. Kegiatan pengabdian masyarakat telah dilakukan tim Farmasi USD tentang edukasi dan screening sindrom metabolik pada kelompok lansia posyandu Danurejan pada tanggal 20 Juni 2022 dengan jumlah peserta 38 lansia. Sebagian besar lansia mengalami obesitas sentral (66%). Berdasarkan sindrom metabolik, terdapat 29 lansia (76%) dengan systole di atas 130 mmHg dan 16 lansia (42%) dengan diastole di atas 85 mmHg. Rerata tingkat pengetahuan tentang sindrom metabolik sebesar 58,57%. Pemeliharaan kesehatan khususnya pencegahan dan dampak sindrom metabolik perlu dilakukan terutama di kalangan lansia pada masa pandemi, sehingga kelompok populasi ini tetap terpantau kesehatannya.

Nonsteroidal anti-inflammatory drugs are used for pain and to slow the progression of rheumatoid arthritis. Accordingly, the discovery of rheumatoid arthritis active compounds from the ethanol-water fraction Coleus atropurpureus (EWC) was conducted to characterize the isolated compounds as well as the anti-rheumatic effects of the EWC induced Complete Freund's Adjuvant (CFA). We conducted in vivo study in rats which were randomly divided into 5 groups. Group 1 was only given CFA as a negative control. Group 2 as positive control was orally exposed to diclofenac potassium (9 mg/BW). Three groups were given different EWCs orally as follows: 11.25 mg/BW, 22.5 mg/BW, and 45 mg/BW, respectively. Rheumatism rates were then compared with positive controls using a visual arthritic scoring system. The compounds identified by isolation of the EWC of Coleus atropurpureus predicted forskolin. The ethanol-water fraction Coleus atropurpureus did not act as an anti-rheumatic arthritis agent in CFA-induced rats.

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