Background: Malocclusion is caused by several factors such as sticking out the tongue, biting the lips, sucking the thumb and biting nails, and breathing through the mouth. This bad habit results in malocclusion which can reduce craniofacial development of orthodontic problems in children. One of the treatments for malocclusion in children with orthodontic problems is the use of myofunctional appliances. Myofunctional devices can properly restore orofacial muscles to normal anatomy. One way to overcome this bad habit is to use myobrace. Myobrace is a three-stage device system specifically designed to treat malocclusion and correct bad habits in children. Objective: To search the literature study on the effectiveness of miobrace in early correction of malocclusion development and in overcoming bad habits in children. Method: Data collection was carried out by searching literature on article search sites, namely Pubmed, Cochrane, Wiley, Google Scholar and Science Direct published from 2016 to 2021. The search was carried out from March to April 2021. Systematic exit using the keyword Malocclusion, Myobrace, Orofacial Myofunctional Therapy.

Objective: Carbamide peroxide 10% is commonly used in home bleaching procedure. Effectiveness of carbamide peroxide bleaching process as a home bleaching has no successor yet, but its use is still being debated due to the effects on oral cavity. Strawberries are one of natural ingredients that currently used to whiten decolorized teeth because it contains ellagic acid and malic acid. On contrary, malic acid is said to be involved in the process of erosion. The aim of this study was to compare tooth enamel hardness after application of dental bleaching agent carbamide peroxide 10% and strawberry gel.Material and Methods: Sample consists of 30 maxillary incisors were divided into 3 groups. The first group as control soaked in aquades. The second treatment group were applied with carbamide peroxide 10%  and a third group applied with strawberry gel. Before and after the sample application, tests were performed to determine the hardness of tooth enamel as measured using Universal Hardness Tester.Results: Based on Friedman test, p-value = 0,000 (p <0,05; significant). This means that there was a significant difference in tooth enamel surface hardness of each group and treatment group using bleaching carbamide peroxide 10% and strawberry gel.Conclusion: There was a decrease on tooth enamel hardness after application of carbamide peroxide 10%  compared strawberry gel.

Objective: To determine the activity of anti-cancer and anti-proliferation of ethyl acetate fraction of ant nest plants (Myrmecodia pendans) in Burkitt's Lymphoma cancer cells. Material and Methods: The study was conducted in a pure laboratory experimental method using Burkitt's Lymphoma cancer cell culture. Gradual research begins with the determination, extraction and fractionation of ant nest plants, to test for proliferation barriers. Data analysis using two-way ANOVA followed by Post Hoc LSD test with a significance level of 95%. Pearson correlation test was conducted. Results: The results of testing the inhibition of Burkitt's Lymphoma cell proliferation with ethyl acetate extract treatment showed that there was inhibition of cell growth based on the concentration given, starting from the lowest concentration of 15.625 µg/mL. Likewise, the incubation time factor of 24, 48, and 72 hours showed that the longer the incubation time, the greater the inhibition of cell growth. Antiproliferation analysis of flavonoid ethyl acetate extract based on concentration and incubation time on absorption of optical density Burkitt's Lymphoma was statistically significant (p = 0.00). Conclusion: Ant nest ethyl acetate extract has the effect of proliferation inhibition on Burkitt's lymphoma cells.

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Objective: To know the influence of immersion length of denture base of acrylic resin in Siwak solution (Salvadora persica) on Candida albicans growth. Material and Methods: This type of research is laboratory experimental. The Siwak plant (Salvadora persica) was extracted and 1% solution was formed. The media used were Sabouraud Dextrose Broth (SDB) and Sabouraud Dextrose Agar (SDA). Candida albicans was cultured as 1 dose in 100 ml of SDB medium, and then incubated at shaker rotation for 1x24 hours. The concentration chosen to test the effectiveness of siwak extract solution was 1%, 10%, 15% and 25%. Data were presented as mean ± SD. Results: Zone of 6 hours Siwak extract immersion inhibitor by 43.47 ± 0.35, 8 hours to know the influence of immersion length of denture base of acrylic resin in Siwak solution (Salvadora persica) on candida albicans growth 44.42 ± 0.02, 10 hours of 52.79 ± 0.03. Conclusion: There is a difference of immersion length of denture base of acrylic resin on Candida albicans growth in Siwak extract solution (Salvadora persica).