Background The aim of this study was to determine the frequency of intermediate alleles (IAs) in ATXN1, ATXN2 and HTT in patients with neurodegenerative diseases. Methods This is a multicentric study that included 1126 Alzheimer disease (AD) , 433 frontotemporal dementia (FTD) and 610 Parkinson´s disease (PD) patients. In all cohorts, we genotyped CAG repeats in ATXN1 and ATXN2 genes. Additionally, in FTD cohort we genotyped CAG repeats in HTT gene. Results In the overall FTD cohort, the frequency of HTT IAs was significantly higher in cases comparatively to controls (6.9% vs. 2.9%; p=0.007.; OR:2.45 (1.30-4.62). The frequency was even higher for c9orf72 expansion negative individuals (7.4% vs. 2.9%; p=0.

alteration in IL-1, adiponectin and oxidative stress levels were found to be related to overweight and obesity; also, iodine levels decreased when BMI increased, contributing to loss of redox equilibrium. All this data may play an important role in etiopathogenesis of chronic disease related to the increase of BMI.

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