The present study was carried out to evaluate in-vitro antioxidant, and thrombolytic activity of MeOH and EtOAc extracts Trema orientalis flowers. Antioxidant activity of the extracts was tested by using DPPH (1, 1diphenyl-2-picrylhydrazyl) free radical scavenging assay method whereas the thrombolytic activity was tested by in-vitro clot lysis assay method. The MeOH extract of T. orientalis showed mild free radical scavenging activity (IC 50 : 131.2µg/ml) compared to ascorbic acid (IC 50 :12.4µg/ml) used as a standard. On the other hand, both MeOH and EtOAc extract produced 21.4 and 21.5% clot lysis respectively compared to streptokinase used as a positive control that caused 51% clot lysis.