For the first time, callus and suspension cultures of Linum linearifolium were initiated. Podophyllotoxin (PTOX), a strong antitumor precursor, was isolated from the calli and suspension, as a main lignan besides smaller amount of 6-methoxypodophyllotoxin (6MPTOX). L. linearifolium is now the third Linum species of section Syllinum, with PTOX as the main lignan. The amounts of lignans, especially PTOX, found in L. linearifolium cell cultures are quite high within the studied Linum species until now. The antiproliferative effects of extracts were tested in a panel of human tumor cell lines, using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide]-dye reduction assay. The lignan mixtures caused concentration-dependent inhibition of malignant cell proliferation and showed moderate cytotoxic activity. The results clearly demonstrate that the lignan mixture of L. linearifolium exerts inhibitory effects against malignant cells.

Abstract-Closed-end real estate investment fund is currently one of the most popular instruments of collective investments in Russia. In this article, we have designed a factor score method to evaluate the investment attractiveness of closed-end real estate investment funds as the objective of the research. The method differs from others in three elements of attractiveness evaluation: the real estate market, asset management company, and asset portfolio. We suggest evaluating each element by the appropriate factors. In the research, all the factors are grouped and systemized as variable-based and attributebased factors in the three elements of investment attractiveness. The evaluation is based on the expert scores and factor criteria. Results of the research show the differences between preferences of conservative, moderate and aggressive investors when they invest in closed-end investment fund. The desighed method serves for different types of investors to express their attitude to a specific real estate closed-end fund.

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