AimTo investigate the use of biomarkers providing independent information regarding physiology in acutely decompensated heart failure (ADHF) for assessment of risk. Methods and resultsThis was a prospective study of 107 patients hospitalized with ADHF (mean age 72 + 13 years, 44% male, left ventricular ejection fraction 47 + 15%). Blood samples were collected on presentation to measure soluble (s)ST2, highsensitivity troponin T (hsTnT), and amino-terminal pro-B type natriuretic peptide (NT-proBNP) levels. Clinical follow-up was obtained for all patients over a median period of 739 days, and all-cause mortality was registered. Concentrations of sST2 [per 10 ng/mL, hazard ratio (HR) 1.09, 95% confidence interval (CI) 1.04-1.13; P , 0.001], hsTnT (per 0.1 ng/mL, HR 1.16, 95% CI 1.09-1.24; P , 0.001), and NT-proBNP (per 100 pg/mL, HR 1.01, 95% CI 1.003-1.01; P , 0.001) were each predictive of a higher risk of death. In bootstrapped models, each biomarker retained independent predictive value for mortality. Patients with all three biomarkers below their optimal cut-off at presentation were free of death (0%) during follow-up, whereas 53% of those with elevations of all three biomarkers had died. For each elevated marker (from 0 to 3) adjusted analysis suggested a tripling of the risk of death (for each elevated marker, HR 2.64, 95% CI 1.63-4.28, P , 0.001). Integrated discrimination analyses indicated that the use of these three markers in a multimarker approach uniquely improved prediction of death. ConclusionsBiomarkers reflecting remodelling (sST2), myonecrosis (hsTnT), and myocardial stretch (NT-proBNP) provide complementary prognostic information in patients with ADHF. When used together, these novel markers provide superior risk stratification.--

AimsTo study the long-term prognostic value of red blood cell distribution width (RDW) in patients hospitalized with acute heart failure (AHF) and to compare the value of this measurement with haemoglobin levels and anaemia status. Methods and resultsDuring a 2-year period, we studied 628 consecutive patients (aged 71 years [interquartile range, IQR: 61 -77], 68% male) hospitalized with AHF. Demographic, clinical, echocardiographic, and laboratory characteristics were registered at discharge and patients were closely followed-up for 38.1 months [16.5-49.1]. Median RDW was 14.4% [13.5 -15.5] and was higher among decedents (15.0% [13.8-16.1] vs. 14.2 [13.3 -15.3], P , 0.001). After adjustment for other prognostic factors in a multivariable Cox proportional-hazards model, RDW remained a significant predictor (P ¼ 0.004, HR 1.072, 95% CI 1.023 -1.124); whereas, haemoglobin or anaemia status did not add prognostic information. RDW levels above the median were associated with a significantly lower survival rate on long-term follow-up (log rank ,0.001). These levels were predictive of death in anaemic patients (n ¼ 263, P ¼ 0.029) and especially in non-anaemic patients (n ¼ 365) (P , 0.001, HR 1.287, 95% CI 1.147-1.445), even after adjustment in the multivariable model. ConclusionHigher RDW levels at discharge were associated with a worse long-term outcome, regardless of haemoglobin levels and anaemia status.--

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