Novel functionalized thiazoles were prepared by the Hantzsch reaction from 3-[(4hydroxyphenyl)carbamothioylamino]-2-methylpropanoic acid and the corresponding α-halocarbonyl compounds in good yields. A series of chemical transformations of the obtained products were carried out, and new functionalized thiazole derivatives with aliphatic, aromatic and heterocyclic substituents were synthesized. 4-Phenyl-substituted N-(4-hydroxyphenyl)-N-carboxyalkylaminothiazoles were used as precursors for the synthesis of bis(thiazol-5-yl)methane derivatives, which then were screened for their antibacterial, antioxidant activities.

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