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Using different kinds of amines, in Fajr-e-Jam gas refinery, including mixed or activated amines, have provided the chance for better analysis of different kinds of amines performance. In the current work, the most important parameters in gas sweetening refineries such as amine circulation rate, steam consumption, CO 2 and mercaptan removal were investigated for sweetening trains utilizing diethanolamine (DEA), methyldiethanolamine (MDEA), DEA/MDEA and activated methyldiethanolamine (aMDEA). In the case of steam consumption and circulation rates, MDEA and aMDEA, show the less required rates to meet lean amine loadings. For CO 2 removal aMDEA has the best efficiency. In the case of mercaptan removal, DEA shows the best absorption rate compared with other three amines.