BackgroundUrinary tract infection (UTI) is a common health care problem. Recurrent UTI (RUTI) in healthy non-pregnant women is defined as three or more episodes of UTI during a twelve month period. Long-term antibiotics have been proposed as a prevention strategy for RUTI. ObjectivesTo determine the e icacy (during and a er) and safety of prophylactic antibiotics used to prevent uncomplicated RUTI in adult nonpregnant women. Search methodsWe searched MEDLINE (from 1966), EMBASE (from 1980), Cochrane Central Register of Controlled Trials (CENTRAL in The Cochrane Library) and reference lists of retrieved articles. Selection criteriaAny published randomised controlled trial where antibiotics were used as prophylactic therapy in RUTI. Data collection and analysisTwo reviewers independently assessed trial quality and extracted data. Statistical analyses were performed using the random e ects model and the results expressed as relative risk (RR) with 95% confidence intervals (CI). Main resultsNineteen studies involving 1120 women were eligible for inclusion. Antibiotics for preventing recurrent urinary tract infection in non-pregnant women (Review)

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