Introduction: A balanced diet plays an important role in the skin. Bioactive substances, i.e. vitamins, minerals, fatty acids, polyphenols, and carotenoids, with a particular focus on their effects on skin condition. The spotlight is on the skin regeneration technique using plasma. Plasma sublimation leaves an intact and dehydrated epidermis layer that acts as a natural biological dressing. Coenzyme Q10 (CoQ10) is a natural constituent of foods and is also often used in functional foods and supplements. Objective: It was to present a systematic review highlighting the main considerations of clinical findings of ocular aesthetic skin treatment such as blepharoplasty with the use of dietary therapy, plasma, and coenzyme Q10. Methods: The systematic review rules (PRISMA) were followed. The search was carried out from February to March 2023 in the Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases, using scientific articles from 2003 to 2023. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 154 articles were found. A total of 58 articles were fully evaluated and 52 were included in this systematic review. Considering the Cochrane tool for risk of bias, 42 studies with a high risk of bias and 24 studies that did not meet the GRADE were removed. Most studies showed homogeneity in their results, with X2 =95.7% >50%. The symmetrical funnel plot does not suggest a risk of bias between small sample-size studies. Results and Conclusion: It was concluded that promoting healthy eating habits can benefit the appearance of the skin, delay aging processes and reduce the risk of skin cancer. It is necessary to differentiate the substances that protect and restore the epidermal barrier, ensuring an adequate level of skin hydration and protecting against external factors and damage induced by inflammation (omega-3 and omega-6 fatty acids). Antioxidants and other phytonutrients that scavenge reactive oxygen species and alleviate oxidative damage to the skin also play an important role in preventing and caring for skin aging. It was inferred that the plasma technique enabled the modeling of the eyelids that should be sculpted, reducing excess skin, improving the appearance of the eyelids, rejuvenating the eyes, and reducing eyelid weight, mainly with the concomitant use of coenzyme Q10. Longwave plasma radiofrequency ablation is an effective treatment for non-surgical blepharoplasty. Plasma application has great potential in ocular aesthetics, however, more clinical and histopathological studies are needed to support previous findings and address some safety and efficacy issues.