No abstract

A number of xanthone derivatives bearing the basic chain of naftifine and butenafine antimycotics in 1, 2, 3, and 4 nuclear positions are described. The in vitro antifungal activity against representative strains of molds and yeasts is reported. Only butenafine xanthone analogues show significant activity against, Cryptococcus neoformans, in particular the regioisomer 4d (1.5 μg/ml).

Allylamine Type Xanthone Antimycotics. -Regioisomeric xanthone derivatives bearing the basic chain of naftifine [cf. (Va)] and butenafine [cf. (Vb)] antimycotics are synthesized and evaluated for their in vitro antifungal activity. -(SALMOIRAGHI, I.; ROSSI, M.; VALENTI, P.; DA RE, P.; Arch.