Objective: Differentiating scrub typhus from other acute febrile illnesses is difficult due to non-specificity of clinical symptoms and relative absence of eschar in Indian population. Antibody based serological tests are mainstay of scrub typhus diagnosis. To order to determine the performance of immunochromatography and IgM ELISA, immunochromatography and scrub typhus IgM ELISA were performed to detect the presence of antibodies against Orientia tsutsugamushi in acute serum of patients with acute febrile illness.
Scrub typhus is a mite-borne infectious disease caused by Orientia tsutsugamushi, a gram-negative intracellular bacterium. It is a severe public health problem that affects mainly Asia-Pacific areas. Scrub typhus threatens one billion people and causes illness worldwide each year. Approximately one-third of the cases may suffer from multiple organ dysfunction syndrome (MODS) during the disease course. Thrombocytopenia is another critical clinical manifestation of scrub typhus, and thrombocytopenia is one of the causes of MODS. Scrub typhus is rare and hard to diagnose and treat. Given the close similarity in the clinical presentation of several tropical illnesses, a meticulous history and detailed physical examination need to be emphasized. In this study, we reported a case of scrub typhus with thrombocytopenia and MODS, which is only the third case worldwide.
w(language varied based on child's mother tongue) in both the groups with or without video (group 2 and 1 respectively).Non-inferiority was pre-defined as difference in procedural duration of < 3 min between the two-arms. Study completeness score (SCS) (maximum of 6-based on the number of viewssub-xiphoid-2/PLAX/PSAX/A4C & A5C/Supra-sternal) and visual analogue scale (VAS) were used to describe study completeness and child's anxiety during echo respectively.Mean duration of echocardiography [263 s vs. 240 s (p value 0.07)], average SCS (5.9 in both groups) and VAS [0.56 vs. 0.92 (p value 0.45)] were not statistically different between the two groups.By pre-specified criteria, audio-group was non-inferior to the video + audio group. Cartoons' audio-content alone, in suitable languages, is an effective pacifier to achieve toddler-echocardiography.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.