This study demonstrates the ability to fabricate lightweight, ductile but mechanically strong magnesium alloy (AZ91D) composites by introducing a small number of high crystalline multi-walled carbon nanotubes. It is demonstrated that 1 % of relatively short and straight carbon nanotubes distributed homogeneously on the outer surface of magnesium powders act as an effective reinforcing filler to prevent deformation, thereby contributing to the enhanced tensile strength of magnesium alloy composites (e.g., from 315 to 388 MPa).Keywords: Carbon nanotubes; Magnesium alloy; Powder processing; Mechanical property There has been strong recent interest in developing lightweight and high-strength materials to improve the energy-efficiency through the weight reduction of automobiles and aircrafts. For these purposes, magnesium alloys have attracted a lot of attention [1-3], as they have low density in its purest form, and in addition, they have been proved to have good mechanical properties through the incorporation of structural filler (e.g., silicon carbide whisker, aluminum and graphite particles, and carbon fibers) [4][5][6][7]. Within this context, the dimensionally nano-sized, mechanically strong, electrically and thermally conductive carbon nanotubes [8][9][10][11], considered to be the ideal reinforcing filler in various composite systems [12][13][14][15], have been incorporated into magnesium matrix [16][17][18][19]. Recently, Goh et al. [19] reported a simple way of preparing nanotube-reinforced magnesium composite by powder-powder mixing and subsequent hot extrusion processes. However, low enhancement (only 5 %), or even a decrease in, tensile strengths in nanotube-reinforced magnesium composites (see Table 3 in ref. 19) could be explained by the presence of aggregated carbon nanotubes within a magnesium matrix. To exploit carbon nanotubes fully as a mechanical reinforcing filler in a magnesium matrix, optimized fabrication processes including homogeneous dispersion of carbon nanotubes must be 1

A cytometrical image analyzing method for nuclear protein was established using WinROOF, a commercially available, inexpensive software, to determine the status of both estrogen and progesterone receptors. Immunohistochemical evaluation of estrogen receptors (ER) and progesterone receptors (PR) was performed with the anti-ER (clone 1D5) and the anti-PR (clone PgR636), respectively, combined with dextran polymer reagent EnVision+, all of which are approved in vitro diagnostics in Japan. The immunostained results were captured as digital images in Windows, and then analyzed in WinROOF with macroinstructions for analyzing each captured area either immunolabeled with chromogen or counterstained with hematoxylin. This image analysis method graded the immunostained nuclei of carcinoma cells based on staining intensities, and calculated the labeling index (LI) for both ER and PR. Furthermore, the LI correlated highly with the results from a histology score (HSCORE) when 20 breast carcinomas were quantified. Regarding ER, when 20% in the LI was considered as the cut-off point for positive, the positivity of ER in computer-assisted analysis was 75% (15 of 20 cases), and was completely concordant with that of HSCORE-based analysis. These results indicate that the cytometrical image analysis-based quantification could be appropriately applied to the objective determination of the immunohistochemical status of both ER and PR.

This study was conducted to elucidate sickness absence due to mental disorders in Japanese companies. Data on sickness absence taken for seven consecutive days or more at eight companies (total number of employees: 44,816) was used for the analysis. Diagnosis of mental disorders was based on medical certificates prepared by physicians. The frequency of absence due to all diseases and mental disorders was 3.0% and 0.3%, respectively. The proportion of frequency absence due to mental disorders compared to that for all diseases was 9.4%. Figures for absence prevalence were almost the same as those for frequency absence. The average length of absence due to mental disorders and non-mental disorders was 119.5 days and 47.3 days, respectively. Rate of absence days due to mental disorders compared to that for all diseases was 21.0%. Percent of sickness absenteeism was 0.4%. In one company, the proportion of frequency absence and rate of absence days due to mental disorders compared to those for all diseases had an increasing tendency over the last six years.

Fifty adult Japanese patients with biopsy-proven idiopathic membranous nephropathy (IMN) were typed for HLA-A, B, and DR antigens, and additional B cell alloantigens designated the MT system. The phenotype frequencies of HLA-DR2 (80.0 vs. 36.0%) and MT1 (96.0 vs. 49.5%) appeared to be significantly increased in the patient group when compared to those of a control. There were lower frequencies of DR4, DRw9, MT3, and MT4 in these particular patients. The decreases of MT3 and MT4 were statistically significant but those of DR4 and DRw9 were not. These results suggest that HLA-DR2 and MT1 antigens are related to the occurrence of IMN in the Japanese population.

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