The purpose of the research is to develop measures for the protection of the Zeravshan river, which is used as an industrial and drinking water supply for the population of several regions of the Republic. Studies have established that the main source of river pollution is industrial enterprise «Navoiazot», which produces mineral fertilizers for needs of agriculture. Discharge of wastewater into the water, leads to pollution of water, and the quality does not correspond to the state standard specification about sources of centralized drinking water supply, about hygienic, technical requirements. At the same time, harmful chemicals are found in the water of the Zeravshan river, which are 2...9 times higher than the MPC installed on them. The medium-term forecast showed that by 2025 the ecological state of the Zeravshan river will not be improved, due to the fact that the production of mineral fertilizers is planned to be increased. In this regard, recommendations on the protection of the Zeravshan river have been developed, which will help to improve the monitoring of the state of the water body and improve the conditions of water use of the population.