Rhizophora apiculata, merupakan jenis tanaman mangrove yang tersebar melimpah di pesisir Indonesia. Populasi tanaman bakau di Indonesia mencapai 75% dari seluruh populasi bakau di dunia. Melimpahnya tanaman ini, belum dimanfaatkan secara optimal. Berdasarkan penelitian terdahulu, diketahui Rhizophora apiculata memiliki beberapa manfaat, salah satunya sebagai antibakteri. Zatantibakteri yang tekandung pada Rhizophora apiculatayaitu tannin, flavonoid dan saponin. Tannin bekerja mengadakan komplek hidrofobik dengan protein, menginaktivasi adhesi, enzim dan protein transport dinding sel, sehingga mengganggu pertumbuhan bakteri. Flavonoid bekerja menghambat sintesis asam nukleat, menghambat fungsi membran sel dan metabolisme energisertamencegah perkembangbiakan bakteri dengan membentuk senyawa kompleks protein ekstraseluler yang akan mengganggu integritas membran sel. Saponin bekerja dengan melisiskan sel bakteri. Berdasarkan penelitian yang telahdi lakukan, ekstrak daun, kulit batang dan akar Rhizophora apiculatadapat menghambat pertumbuhan bakteri Pseudomonas aeruginosa,Staphylococcus aureus, Streptococcus sp, dan Escherichia coli.Tujuandariliterature reviewiniadalah untuk mengetahui potensi Rhizophora apiculatasebagaiantibakteri. Metode yang digunakandalamartikeliniadalahpenelusuran artikel melalui database Google Scholar dan NCBI, lalu artikel dipilih dengan meninjau judul dan abstrak artikel, melibatkan 22 pustaka baik nasional maupun internasional.Hasil dari berbagai penelusuran yang dicantumkan dalam artikel ini untuk menunjukkan adanya potensiRhizophora apiculatasebagaiantibakteri.  Kata kunci: rhizophora apiculata, zatantibakteri, kandunganrhizophora apiculata   EFFECT ANTIMICROBACTERIAL RHIZOPHORA APICULTA FOR INHIBITS GROWTH OF BACTERIA   ABSTRACT Rhizophora apiculata is a type of mangrove that is spread abundantly in the coastal areas of Indonesia. The population of mangroves in Indonesia reaches 75% of the total mangrove population in the world. The abundance of mangroves in Indonesia has not been used optimally. Based on previous research, it is known that Rhizophora apiculata has several benefits, one of them is as an antibacterial. Anti-bacterial substance found in Rhizophora apiculata are tannin, flavonoid and saponin. Tannin works by holding a hydrophobic complex with protein, inactivates adhesion, enzymes and protein transport of cell walls, thereby disturb of bacterial growth. Flavonoids, work to inhibit nucleic acid synthesis, inhibit cells membrane function and inhibit energy metabolism and prevent bacterial proliferation by forming extracellular protein complex compounds that will disturb membrane cell integrity. Saponin as an antibacterial, works by lysis of bacterial cells. Based on several studies that have been done, leaf, bark and roots extracts of Rhizophora apiculata can inhibit the growth of the bacteria Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus sp. and Escherichia coli. Rhizophora apiculata has an effect in inhabiting the growth of certain bacteria.The purpose of this literature review article is to get to know about the potency of Rhizophora apiculata as an antibacterial. The method used in this article uses a review of articles from Google Scholar and NCBI databases, then the article are selected by reviewing the article titles and abstracts, involving 22 libraries both national and international.The results of various articles included in this article are to show the potency of Rhizophora apiculata as an antibacterial.   Keywords: rhizophora apiculata, anti-bacterial substance, content of rhizophora apiculata

Background: Rhizophora apiculata, one of the mangrove plant widely spread in Indonesia, can be developed as a medicinal plant. The extract of the bark has been found to have antioxidant and anti-inflammatory. However, the toxicity of Rhizophora apiculata has not been established yet.Objective: This research aims to evaluate the toxicity of ethanolic extract of Rhizophora apiculata bark on histopathological changes in rat’s liver and pancreas.Methods: Subacute toxicity study of the ethanol extract of Rhizophora apiculata bark was performed in healthy male rats by administering the extract at doses of 57, 114, 228, 456, and 918 mg/kg of body weight daily for 28 days. The subacute toxicity in rats was determined by histological analyses.Results: No significant adverse effect of the extract at dose 57 mg/kg was found. However at and over 114 mg/kg dose of the extract exhibited toxicities to the rats’ liver. In addition, the toxic effect appeared in rats’ pancreas at and over 228 mg/kg dose.Conclusions: Rhizophora apiculata bark extract showed no toxicity at or below 57 mg/kg. The ethanol extract from bark of Rhizophora apiculata showed toxicity at 114 mg/kg by subchronic toxicity.