Melon (Cucumis melo L.) is a potential seasonal fruit crop. In melon cultivation, farmers combine various inputs. Combined inputs such as land, seeds, organic fertilizers, inorganic fertilizers, pesticides, labor. Organic fertilizer is now a promising method for sustainable agriculture where it is most affordable compared to synthetic fertilizers. The objectives of this study were (1) to determine the technical efficiency (ET) of melon farming, (2) to determine the effect of manure on melon production. (3) To determine the effect of age, formal education and farmer experience on the use of manure. Giriwoyo sub-district was chosen as the research location because it has the largest area of harvested land and the highest amount of melon farming production in Wonogiri Regency. Selection of farmer samples using accidental sampling technique. The number of respondents was 60 farmers. The conclusion from the results of the study that (1) the average technical efficiency of melon farmers is 96.7% classified as high criteria, (2) manure has a positive effect on melon production, thus the use of manure can increase melon production which will further increase technical efficiency. (3) Age, education and experience have a positive effect on the use of manure. The suggestions given are (1) to increase technical efficiency can be done by adding manure and (2) increasing the use of manure can be done by increasing age, education and experience. Increasing age as a proxy for information, namely by adding information, increasing knowledge with training and increasing experience can be improved by apprenticeship activities with other parties. Experience is a key factor to increase the use of manure.