We have reported that heparan sulfate (HS)/heparan sulfate proteoglycan (HSPG, syndecan-1) expression significantly increased in the rat kidney during calcium oxalate (CaOx) normal conditions. However, calcium oxalate crystal attachment was apparently decreased in the KIC-synd-1 cells. These results suggested that cell surface HS/syndecan-1 has preventive role for calcium oxalate nephrolithiasis via creation of a charge barrier against COM crystal attachment.
Summary
Jelly‐like matrix taken from a lesion of digital mucous cyst (DMC) was analysed with cellulose acetate paper electrophoresis and an enzymatic digestion‐high performance liquid chromato‐graph method and compared qualitatively and quantitatively with that from a ganglion. The ratio of glycoconjugate to the total solid components was extremely high in matrix from DMC, while only less than 1% in that from ganglion. In the former the greater part of glycoconjugate was glycosaminoglycans (GAGs) consisting mainly of hyaluronic acid, while in the latter glycoprotein dominated and the amount of GAGs was very small.
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