The present study was commenced to judge ethnomedicinal worth of the plant. We tried to analyze in vitro thrombolytic and membrane stabilising activities of methanolic extracts of Avicennia marina. Crude methanolic extracts of A. marina leaves & barks at numerous conc. were used for in vitro thrombolytic and membrane stabilising activities. Just in case of thrombolytic study, it absolutely was dose dependently accumulated, wherever 10 mg/ml concentration most importantly showed 13.22% lysis of clot (p<0.001) by in vitro clot lysis assay technique. Streptokinase was used as standard & water was treated as negative management. Crude methanolic extracts of A. marina dose dependently increased in membrane stabilising study, whereas 10 mg/ml concentration most importantly showed 10.11% & 22.23% inhibition of haemolysis severally by both hypotonic solution and heat induced haemolysis of RBC membrane. Acetyl salicylic acid was used as standard in membrane stabilising study.

The objective of this study was to analysis in vitro release kinetics of Azithromycin from bi-layer tablets prepared by direct compression using high viscosity to low viscosity grades of hydroxypropyl methyl cellulose (HPMC K15M, HPMC K4M, HPMC 50 cps), Carbopol 934p and Carbopol 974p. In addition, it also includes evaluating the effect of formulation variables like polymer proportion and polymer viscosity on the release of Azithromycin. In vitro release studies were performed using USP Type-II (Rotating paddle method) at 100 rpm. The dissolution medium consisted of 0.1N HCl (900 ml) for the first 2 hr and the phosphate buffer (pH 6.0) from 3 rd to 10 th hour. From twenty five different formulations (F-1 to F-25) based on polymer variation, model-dependent and independent methods were used for data analysis and the best results were observed for HPMC 50cps in Korsmeyer-Peppas (R 2 =0.995 on F-23) kinetic model. The release mechanism of all formulations was Fickian.

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Background: Menstrual cycle is a normal physiological incident in the life of a girl. Often it is not properly understanded or realised that, maintaining a proper hygiene and the symptom management play a vital role in leading a healthy life for a woman. The condition is even worse in developing countries. The aim of the study is to assay the effects, pattern of the cycle and symptom management among the educated female populations in Tangail region in Bangladesh.Methods: A cross sectional study was conducted in Tangail with 305 participants. Data collection took place from October,2020 to December, 2020 following a structured questionnaire. The data obtained were analysed through SPSS 23.0 version.Results: Among the study population 61.5% were in the age range from 20-30 years. Most of the participants have done their post graduation (42.4%). The daily water intake is really important for a good menstrual cycle. 40.8% of the female take less than 2 litres of water which is alarming. 78.3% having their cycle regular with 68.8% of normal flow. 70.4% having their cycle for 3-5 days which is okay. 53.6% of the participants faces Premenstrual syndrome for which 12.2% take medications and 18.8% participants take medicine during menstruation. The study demonstrates a statistically significant association between the age and PMS as well as between the life stress of a women and PMS.Conclusions: The study's goal is to look into the effects and management of menstruation, as well as the demographic and lifestyle characteristics of the participants. To ensure female's health, menstrual cycles must be maintained properly.