Pyroptosis is a type of programmed cell death mediated by a multiprotein complex called the inflammasome through the pro-inflammatory activity of gasdermin D. This study aimed to recognize the final biological product that leads to pore formation in the cell membrane, lysis, pro-inflammatory cytokines release, and the establishment of an immune response. An exhaustive search engine investigation of an elevated immune response can induce a sustained inflammation that directly links this mechanism to non-alcoholic fatty liver disease and its progression to non-alcoholic steatohepatitis. Clinical studies and systematic reviews suggest that gasdermin D is a critical molecule between the immune response and the disease manifestation, which could be considered a therapeutic target for highly prevalent diseases characterized by presenting perpetuated inflammatory processes. Both basic and clinical research show evidence on the expression and regulation of the inflammasome-gasdermin D-pyroptosis trinomial for the progression of non-alcoholic fatty liver disease to non-alcoholic steatohepatitis.publication elsewhere, in whole or in part. We have not had any competing financial interests or commercial relationships that might pose a conflict of interest regarding the submitted manuscript. In case of acceptance, the copyright is transferred to the Journal of Gastroenterology and Hepatology. Author contribution: All authors have contributed to the article's development and improvement; they also agreed on the manuscript's content. Itzayana Rodríguez-Antonio, Guillermo N. López-Sánchez, and Natalia Nuño-Lámbarri designed and wrote the article. Norberto C. Chávez-Tapia and Misael Uribe reviewed, contributed various ideas, and corrected the manuscript's final version.Financial support: This research did not receive any specific grants from funding agencies in the public, commercial, or nonprofit sectors.

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