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The aim of the research was to study the correction of ossification processes and the mechanisms of humoral regulation of this process in the pathology of vitamin-mineral metabolism against the background of an immunosuppressive state in piglets. As a result of the experiment, it was found that proposed pharmacological correction scheme contributes to an increase in the level of total calcium (3.48 ± 0.29 mmol/l), ionized calcium (1.65 ± 0.07 mmol/l), ion-exchange calcium (2.52 ± 0.05 mmol/l), and protein-bound calcium (0.54 ± 0.06 mmol/l), 2, 3-diphosphoglycerate (1.43 ± 0.02 mmol/l), vitamin A (2.63 ± 0.09 μg/l), citric acid (2.90 ± 0.16 μg/l), a significant decrease in alkaline phosphatase activity (2.02 ± 0.04 mmol/l). Optimization of the structural and functional organization of the thyroid and parathyroid glands was noted, activation of hematopoiesis and bone tissue remodeling was observed in bone tissue, which suggests a pronounced reparative and osteoprotective effect of the proposed pharmacocorrection scheme.

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ФГБОУ ВО «Казанская государственная академия ветеринарной медицины имени Н.Э. Баумана» (ФГБОУ ВО Казанская ГАВМ) FSBEI HE «Kazan Bauman State Academy of Veterinary Medicine»(FSBEI HE KSAVM) Печатается по решению редакционной коллегии Казанской государственной академии ветеринарной медицины им. Н.Э. Баумана от 15 Сентября 2018 г