Abstract:The aim of this paper is to analyse and estimate the efficiency of health information systems in the provision of health care services. The evaluation of health information systems is conducted in the case of three most widely used softwares in the electronic health care. This evaluation is based on multi-criteria analysis of the health information systems efficiency using the AHP-TOPSIS method. This method, based on common attributes and their respective values for all three software solutions, individually determines the best rated software solution. Top rated software solution of electronic health care is not necessarily the best for the implementation and development, given the fact that each health care organisation has its own characteristics. Functional and evolutionary-minded hardware and software applicative infrastructure contributes to the consistency of electronic health concept that all system users provides a comfortable software solutions, which ultimately leads to the timely and quick medical services in real time.