Defek tulang merupakan salah satu manifestasi klinis terjadinya periodontitis dimana pada kondisi tersebut terjadi inflamasi pada jaringan periodontal. RANKL adalah salah satu reseptor pada permukaan osteoblast yang level ekspresinya akan mengalami peningkatan ketika terjadi inflamasi sehingga dapat merangsang osteoclastgenesis yang mengakibatkan resorbsi/defek tulang alveolar. PRF merupakan fibrin matriks generasi terbaru dari platelet concentrate yang didalamnya terdapat growth factor yang bisa mendukung terjadinya regenerasi tulang Tujuan: Tujuan dari penelitian ini adalah untuk mengetahui perbedaan ekspresi RANKL pada defek dengan pemberian xenograft dibandingkan dengan pemberian xenograft+PRF. Metode: delapan belas kelinci New Zealand jantan dibagi menjadi 3 kelompok yaitu Kelompok 1 (pemberian Xenograft), kelompok 2 (pemberian PRF) dan kelompok 3 (pemberian xenograft+PRF). Defek tulang dibuat pada tulang tibia kelinci (kedalaman 3mm dan diameter 5mm) kemudian diaplikasikan bahan penelitian pada defek. Setelah 30 hari sampel jaringan diambil dan dilakukan pewarnaan imunohistokimia untuk mengetahui ekspresi RANKL. Hasil: Ekspresi RANKL terbanyak terdapat pada kelompok 1 kemudian diikuti oleh kelompok 2 dan kemudian kelompok 3 (paling sedikit). Terdapat perbedaan signifikan antara kelompok satu dibandingkan dengan kelompok 2 dan 3. Kesimpulan: Aplikasi xenograft+PRF pada defek memiliki kemampuan osteogenesis yang lebih baik dibandingkan hanya xenograft saja.

Background: Elimination of subgingival plaque for prevention and treatment of periodontal diseases through scaling is a routine

The inflammatory enlargement is clinically called hyperthropic gingivitis or gingival hyperplasia and generally related to local or systemic factors. They could be edematous or fibrous. The former is treated by scaling, but the latter that could not be treated by scaling only has to be removed by gingivectomy. There are some cases of gingivectomy resulting in recurrences. The writer wanted to find out the cause of the recurrences. The types of research were clinical and laboratories observational studies. The criteria of sample were: male or female patient who came to periodontal clinic of Faculty of Dentistry Airlangga University. They were diagnosed gingivitis hyperplasia; had no systemic diseases; did not wear the orthodontic appliances, prosthesis, and crown and bridge; do not smoke. The indicated teeth to be observed were the labial side of maxillary front teeth. The teeth had score hyperplastic index (HI) = 2 at the 2 nd weeks after scaling. There were 7 samples taken selectively. The results of the studies were based on the comparison of 1) hyperplasia index (HI); 2) the number and percentage of monosite and leucocytes from white blood impedance coutl (WIC) and white blood optical coutl (WOC); 3) plaque Index; and 4) gingival index. The result of gingivectomy was reevaluated on the 30 th , 45 th , 60 th , 90 th day. The research concluded that the number of monosite was normal, but the dental plaque still accumulated and eventually caused the recurrences of the inflammation.

Background: Periodontal diseases are associated with bacteria species which present in biofilms that colonize on dental surfaces. Several tooth brushing methods had been known and proved to be effective in maintaining oral hygiene. Among them, tooth pick technique was a relatively new method and its superiority in removing interproximal plaque was better than other methods. Purpose: The purpose of this study was to examine the effectivity of toothpick tooth brushing method to conventional method on periodontal health. Methods: This research was designed as an analytical observational study. Thirty samples selected from five hundred and twelve males Indonesian Air-force members in Malang, aged 18-40 yrs, with periodontal pockets (≤ 5 mm) in upper or lower teeth, without crowding, gingival index minimal > 1 (moderate gingivitis), OHI-S score minimal ≥ 1.3 (moderate), without systemic diseases, do not undergone medical therapy/drug prescriptions, without using mouth rinse during study, and without prosthesis. There were thirty samples in this research and devided to two groups, fifteen samples easch. The groups were toothpick tooth brusing method and conventional method (control group). In this study oral hygiene index simplified (OHI-S), gingival index (GI), bleeding on probing (BOP) and pocket depth were examined. Results: There were significant differences (p = .001) in OHI-S, GI, BOP, and PD before and after conducting each toothbrushing method, as well as differences between means (quarrel means), that were p = .003; p = .001; p = .001 and p = .001 consecutively. Conclusion: Toothpick brushing method was more effective in plaque control compared to conventional method.