The aim of this study was to investigate the relationship between social isolation, illness anxiety and quality of life in corona survivors. This paper focuses on moderating role of illness anxiety on the relationship between social isolation and quality of life of COVID-19 survivors who faced this disease in past 6 months. The sample comprised of 110 survivors of COVID-19. Purposive sampling was used to assess the participants with the help of Google forms. Social isolation was measured by using Lubben Social Network Scale (Lubben et al., 2006), quality of life was measured by WHOQOL-BREF (World Health Organization, 1996), and to measure illness anxiety Hamilton Anxiety Rating Scale (Hamilton, 1959) was used. Correlational analysis revealed that social isolation had positive relationship with illness anxiety. Illness anxiety had negative relationship with physical health, psychological health environment and overall quality of life. Moreover, moderation analysis revealed that illness anxiety significantly moderated the relationship between social isolation and quality of life. This research attempted to explore the social isolation during lock down and illness anxiety corporate in low quality of life in COVID-19 pandemic. This study has variety of clinical implications as this research gave us insight into the role of social isolation and illness anxiety on quality of life especially in this pandemic so it will help psychologists to take measurements accordingly.