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Synthesis and Reactions of 3-Cinnamoyl Coumarin Derivatives with Activated Nitriles. -Various new coumarins are prepared with a view to their possible biological activity. -(MIKY, J. A. A.; FARRAG, A. A.; Indian

Both visnaginone and khellinone react with malononitrile, ethyl cyanoacetate or cyanoacetamide in presence of ammonium acetate to give substituted furobenzopyrans or furobenzopyridones.However, the reaction of visnaginone and khellinone with aldehydes, and malononitrile in presence of ammonium acetate leads to the formation of the corresponding 2-amino-4,6-disubstituted pyridine 3-carbonitriles. The latter compounds are also obtained by treating the respective chalcones with malononitrile and ammonium acetate.3-Substituted 1,3-diketobutyrates form with malononitrile or with cyanoacetamide and ammonium acetate the 2-amino-4,6-disubstituted pyridine-3-carbonitriles or the 4,6-di-substituted cyanopyridones, respectively

The condensation reaction of the benzofuran derivatives (I) with activated methylene compounds such as (II), (IV), or (VI) yields the corresponding pyridines (III), (V), and (VII) respectively.

Synthesis and Biological Activities of 5H-Furo[3,2-g][1]benzopyran-5one Derivatives.-A variety of hitherto unknown derivatives of visnagin (Ia) and khellin (Ib) are synthesized and evaluated for their effects on blood pressure. -(MIKY, J. A. A.; SHARAF, H. H.; Indian J. Chem., Sect. B: