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The median time to achieve normocalcaemia was 4 days (range 2-14) for pamidronate and 3 days (range 2-6) with clodronate. The median duration of normnocalcaemia was 28 days (range 10-28 + days) after pamidronate and 14 days after clodronate (range 7-21 days) (P<0.01). Two patients who failed to respond to clodronate were successfully treated with pamidronate and achieved normocalcaemia for 14 and >28 days respectively. Two patients experienced fever after pamidronate but no significant toxicity was observed with either treatment. We conclude that both agents are effective in the management of hypercalcaemia of malignancy. At the doses studied. the effects of pamidronate are more complete and longer lasting than those of clodronate.

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