The case of a 20 year old woman is reported with Budd-Chiari

No abstract

No abstract

To determine whether profiles of decreasing concentration were generated among hepatocytes of the liver acinus during the transport of sulfobromophthalein sodium (BSP), rat livers were perfused with various concentrations of this dye (10 microM to 1 mM) in the presence and absence of albumin. After steady-state conditions for the biliary secretion of BSP had been attained, pieces of liver were rapidly frozen. Following the alkalinization of cryostat-cut sections, the relative concentration of BSP in hepatocytes of each zone and the effect of albumin on this localization were quantitated by microspectrophotometry. The results showed that BSP, perfused in the absence of albumin, was efficiently extracted by the liver (95% on a single pass), generating distinct profiles of decreasing cellular concentration from zone 1 to zone 3 at every concentration of BSP. However, the addition of albumin to the perfusate greatly reduced the extraction of BSP from the sinusoidal compartment and resulted in the abolition of the differences in BSP content between hepatocytes of zone 1 and zone 3. These results represent a direct demonstration that, as predicted by mathematical modeling, binding of BSP to albumin indeed results in a more homogeneous distribution of BSP within the liver acinus. A simple and direct microspectrophotometric method is therefore available to follow the changes in the relative concentration of BSP among the hepatocytes of the various acinar zones.

BRTISH MEDICAL JOURNAL 26 JUNE 1971 749 (Fig. 1); after 18 days a cystogram showed only a small extravastion (Fig. 2); and 32 days after operation the bladder appeared normal and the catheter was removed. By this time the penneal wound was healed and the anal sphincter was felt to be intact Forty-seven days after the initial injury the colostomy was dosed and the patient was discharged home, continent of urine and faeces.lIG.-Ca. e 2.. ' Int u pelo aEn.'..S I 11I1 .SiX days after operation.