A 51-year-old promiscuous heterosexual man with no history of venereal diseases or porphyria had a large genital chancre and deep erosions on the hands. The HIV serology was positive; the CD4 lymphocyte count was 187/mm3 but the patient did not fulfill the CDC criteria for AIDS. Five months later he developed a clinical and biochemically typical porphyria cutanea tarda.
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