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Objectives:To compare IOTA Simple Rules with RMI-2 as a screening tool for adnexal mass diagnosis in a tertiary care centre in Canada. Methods: A retrospective cohort study was conducted on patients who underwent surgery after ultrasound diagnosis of adnexal masses. Ultrasound evaluation was performed in a tertiary care referral centre for Gynecological Oncology and RMI-2 scores calculated. Patients were triaged to the appropriated surgical service based on RMI-2 scores. RMI-2 scores >200 were referred to Gynecological Oncology Service whereas patients scoring <200 were referred to General Gynecology Service. Application of IOTA Simple Rules was carried out by an IOTA certified sonologist blinded to the RMI-2 scores, clinical follow-up and final pathological diagnosis. Objectives: To compare RMI-2 performance with subjective sonographic assessment for discrimination of benign vs. malignant adnexal masses. Methods: A retrospective cohort study was conducted on patients who underwent surgery after ultrasound diagnosis of adnexal masses. Ultrasound evaluation was performed in a tertiary care referral centre for Gynecological Oncology and RMI-2 scores calculated. Patients were triaged to the appropriated surgical service based on RMI-2 scores. RMI-2 scores >200 were referred to Gynecological Oncology Service whereas patients scoring <200 were referred to General Gynecology Service. Subjective assessment was carried out by a senior sonologist blinded to the RMI-2 scores, clinical follow-up and final pathological diagnosis. Standard measures of screening test performance (i.e. sensitivity, specificity, positive-and negative-predictive values (PPV, NPV)) were calculated for the subjective sonographic assessment and RMI-2 and compared with gold standard (pathology diagnoses). Objectives: To evaluate the diagnostic accuracy of TVUS in the preoperative detection of deep myometrial infiltration (MI) in patients with endometrial cancer (EC), using the surgical-pathologic data as a reference standard. Methods: An extensive search was performed in Medline (Pubmed) and EMBASE from January 1989 to January 2015. Quality was assessed using QUADAS-2 tool. Results: Our extended search identified 184 citations but we finally examined the full text of the 30 articles. Overall pooled sensitivity, specificity, positive likelihood ratio (LR+) and negative likelihood ratio (LR-) of TVS for detecting deep myometrial infiltration was 82% (95% CI, 76-87%), 81% (95% CI, 76-85%), respectively. We did not observe differences among all three methods in terms of diagnostic performance. Significant heterogeneity was found for sensitivity and specificity for all three methods (I2 values ranging from 60.57 to 94.96). Conclusions: Overall diagnostic performance of TVS for detecting deep myometrial infiltration in women with endometrial cancer is acceptable. However, more studies with improved quality in design and using TVUS only in low risk cases and comparing several approaches in the same set of women are needed.

Short oral presentation abstracts OP07.08 A preliminary comparison of the IOTA simple rules with the risk of malignancy index RMI-2 for the evaluation of adnexal masses within a Canadian tertiary care centre