With increasing worldwide rates of morbidity and mortality of pulmonary fibrosis, the development of effective therapeutics for this disease is of great interest. Secretoglobin (SCGB) 3A2, a novel cytokine-like molecule predominantly expressed in pulmonary airways epithelium, exhibits anti-inflammatory and growth factor activities. In the current study SCGB3A2 was found to inhibit TGF␤-induced differentiation of fibroblasts to myofibroblasts, a hallmark of the fibrogenic process, using pulmonary fibroblasts isolated from adult mice. This induction was through increased phosphorylation of STAT1 and expression of SMAD7 and decreased phosphorylation of SMAD2 and SMAD3. To demonstrate the effect of SCGB3A2 on the TGF␤ signaling in vivo, a bleomycin-induced pulmonary fibrosis mouse model was used. Mice were administered bleomycin intratracheally followed by intravenous injection of recombinant SCGB3A2. Histological examination in conjunction with inflammatory cell counts in bronchoalveolar lavage fluids demonstrated that SCGB3A2 suppressed bleomycin-induced pulmonary fibrosis. Microarray analysis was carried out using RNAs from lungs of bleomycin-treated mice with or without SCGB3A2 and normal mice treated with SCGB3A2. The results demonstrated that SCGB3A2 affects TGF␤ signaling and reduces the expression of genes involved in fibrosis. This study suggests the potential utility of SCGB3A2 for targeting TGF␤ signaling in the treatment of pulmonary fibrosis.

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strands of the cable. strands of the superconducting cable, and current differences between the superconducting filaments, eddy currents flowing in and between the measurements of the field errors resulting from persistent currents in the the range of those expected for the accelerator operation. We present of the measurements of the field quality is given for current variations in at CERN as model magnets for the future LHC particle accelerator. Results Several superconducting dipole magnets were manufactured in industry or

commissioning are described. magnets. The bench and its performance and precision achieved during its an important issue during production measurements of large series of automated, computer-controlled operation requiring a minimum of staff, emphasis has been put on the user-friendliness of the bench and its placed outside the magnetic field without space restrictions. Particular motor, an angular encoder and a level meter, all standard components very high rotational stiffness and which is controlled from its far end by a mounted at one end of a 12.5 m long shaft which is specially designed for at room temperature. This coil, together with Hall and NMR detectors is installed inside the magnet cold bore, thus allowing the use of rotating coils integrals. The measurements will be carried out along a warm bore content of higher harmonic field components, field direction and field The magnetic measurement of more than 1300 LHC dipoles comprises the Ahstrggt ].

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