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Separation of metabolites of Penicillium vermiculatum DANG present in the cultivation medium afforded three new antibiotics; vermiculinel), vermistatin2) and vermicillin3) . The structure of vermiculine, a macrolide dilactone has already been solved by X-ray diffraction analysis". This paper presents the structure elucidation of the second compound of this series, vermistatin.In our previous paper2) we reported the isolation, antibiotic and cytotoxic activity of vermistatin (1); it is a white crystalline compound of molecular formula C,,H,,O, (328

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VermixocinsA and B, 3-(r-hydroxy-3'-methylbutyl)-and 3-(r-acetoxy-3'-methylbutyl)-l lhydroxy-4-methoxy-9-methyl-5//,7/f-dibenzo [c,/] respectively. A new strain, specified B 5, selected from the above mentioned parental strain formed dehydroaltenusin only4). This compoundin addition to other polyketide metabolites was isolated from the mycelium of T. flavus (ATCC52201) grown on a malt extract medium5). Two new minor metabolites designated vermixocins A (1) and B (2) were found in the mycelium of P. vermiculatum cultivated under conditions optimized for vermiculin production. The structure elucidation of compounds1 and 2 is the subject of this report.