A case of juvenile nasopliaryngeal angiofibronia trcatcd preoperatively first w i t h antlrogcii and then writ11 estrogen is rcported. I;nder androgeii therapy tlic tumor appe:n-cd to enlarge sonicwliat. T h i s w a s followed h y ;I conrse o f estrogen tlicrapy wliicli rcsultctl in a prompt and d r n i~i a t i c involution antl decrease i n size o f the tumor. It became w r y firni antl permitted cv~rlsioii with a iiiiniiiial ((i00 c c ) blood loss for this type of tunlor. Thc response of this tnnior to cstrogcn w a s similar to tliat found by one of the authors in four previously unreported cases. Pul i c r o sc 01) i c 11 i c t ur e s sh owe (1 a d r a i i i at ic fibrosis wit I i 111 at lira t ion of t h c vascttlar and connective tissue elciiients. Prroperativc estrogen therapy is recoiiimendcd :IS :I supplciiicnt but not :I snbstitute for surgery. 'I'lic Mood loss is definitely clecreascd. Acta Otolaryngol Downloaded from informahealthcare.com by Monash University on 08/25/15 For personal use only. A c f a oto-larung. GI Acta Otolaryngol Downloaded from informahealthcare.com by Monash University on 08/25/15 For personal use only. Acfci oto-Iargng. 61 Acta Otolaryngol Downloaded from informahealthcare.com by Monash University on 08/25/15 For personal use only. S l ecn Joli n sen, ,II .I) ., ENT I k p r i ni e n t , G f o s f r n p Hospiftrl, Copenliciyen I)enmcrrf Heceiried Jnne 16, 1!)65 Acfa ofo-lnryng. 61 Acta Otolaryngol Downloaded from informahealthcare.com by Monash University on 08/25/15 For personal use only.