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Abstract

Differential protein clearances were carried out in 31 patients with toxaemia of pregnancy and in 21 non-toxaemic patients with abruptio placentae. In 6 patients with toxaemia and in 7 with abruptio placentae, dextran clearance determinations were also performed. Results were expressed in terms of selectivity indices relating the clearances of these macromolecules to their molecular weights. In toxaemia, protein and dextran selectivity results were in the intermediate range, dextran values being slightly higher than the values obtained for protein. In abruptio placentae, however, the values obtained for protein selectivity were very low, while those obtained for dextran selectivity were very high. These results suggest that in toxaemia the proteinuria is of glomerular origin, but that in abruptio placentae the urinary protein is post-glomerular and is derived from plasma protein passing through damaged renal tubular epithelium.

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