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Deer Island Flats, Boston Harbor, Massachusetts, USA, is a n area that is heavily contaminated with organic and inorganic chemicals. At this site winter flounder Pleuronectes americanus have been found to have a high prevalence of hepatic lesions including neoplasms. We describe here the relative frequency and histology of different tumor types in a sample of 60 neoplasms from 29 fish. Nlnety percent of tumors were cholangiocellular and ranged from cholangiomas to tubular, scirrhous, solid or cystic anaplastic cholangiocarcinomas. Hepatocellular tumors were also occasionally present (10%). The majority of tumors were closely associated with hydropically vacuolated cholangiocytes and hepatocytes, often being observed within grossly visible aggregations of vacuolated cells, and with vacuolated cells at their advancing margins. Vacuolated cells may be involved in the progression to neoplasia.

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