J. Jambrosic scite author profile

A human melanoma variant cell line was obtained from a lung metastasis that arose spontaneously after we inoculated melanoma cells sc into a nude mouse. In this model, IgG2a monoclonal antibody (MAb) ME 36.1 defining the GD2/GD3 gangliosides inhibited melanoma growth at the primary site and metastatic spread of the cells, whereas an IgG1 variant of MAb ME 36.1 inhibited lung metastasis formation only. Possible mechanisms of antitumor effects of MAb ME 36.1 are discussed.

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Growth and Phenotoypic Characteristics of Human Nevus Cells in Culture

Mancianti¹,

Herlyn²,

Weil³

et al. 1988

Journal of Investigative Dermatology

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J. Jambrosic

Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression.

Regulatory factors that determine growth and phenotype of normal human melanocytes*1

Inhibition of Metastases of a Human Melanoma Xenograft by Monoclonal Antibody to the GD2/GD3 Gangliosides

Growth and Phenotoypic Characteristics of Human Nevus Cells in Culture

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