Introduction: The spleen is a largest collection of lymphoid tissue with peculiar anatomical and physiological features. Spleen plays an important role in fetal hematopoiesis and immunomodulation. The aim of the study is to perform detailed histological analysis of human fetal splenic specimens of various gestational ages  and compare the findings with earlier studies. Material and  Methods:  The  present  study  included  40  fetal cadaveric spleen and  morphometric features i.e., weight was measured and the sections of the spleen were stained  with Haematoxylin and Eosin stain and were observed under compound light microscope Results: In the present study the histology of spleens of prenatal group showed the well defined red pulp, venous sinusoids and diffusely spread lymphocytes at 18 weeks of gestation and the organization of lymphoid follicles was noticed at 24-28 weeks. At 32 weeks well defined white pulp was observed and the microscopic architecture of the spleen was similar to the histology of adult spleen. Conclusion: A detailed knowledge of splenic morphometric dimensions, Histology and Histogenesis is crucial in deciphering the role of spleen in fetal development and fetal wellbeing. Key words: spleen, hematopoietic, microscopic,  fetal

Introduction:The spleen is the largest hemolymphatic organ of the human body that plays a significant role in Hematopoiesis and immune phagocytosis. Recent studies have emphasized the importance of spleen as hematopoietic organ in fetal period, role in synthesis of immunoglobulins & defense of human body against infections. A thorough knowledge of splenic morphometry and dimensions is vital in comprehending the development of spleen in fetal period.Aim:The aim of the study is to study detailed morphometric analysis  human fetal splenic specimens of various gestational ages  and compare the findings with earlier studiesSubjects and Methods:The  present  study  included  40  fetal cadaveric spleen and  morphometric features i.e.,length, breadth, width and weight of spleen were measured.Results:The average weight of the fetal spleen was 1.98 gm and varied from 0.1 to 5.1 gm. The average length, breadth and width of spleen in prenatal group were 2.21 cm, 1.39 cm and 0.645 cm respectively. In the present study the average weight of the fetal spleen was 1.98 gm and varied from 0.1 to 5.1 gm. There was statistically significant increase in splenic weight till 33 weeks.Conclusion:Knowledge of spleen size at different gestational ages will help in early detection and diagnosis of splenic anomalies, identifying congenital malformations, early diagnosis and prompt treatment of intrauterine infections.